Sjogren's Syndrome
July 2023 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Sjogren's Syndrome abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Sjogren's Syndrome. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Sjogren's Syndrome. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Sjogren's Syndrome every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Clinical course and risk factors for development and progression of interstitial lung disease in primary Sjögren's syndrome.
Authors:Lee KA, Nam BD, Hwang JH, Kim HS
Institution:Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, 59 Daesagwan-ro, Yongsan-gu, Seoul, 04401, South Korea.
Journal:Sci Rep. 2023 Jun 6;13(1):9189. doi: 10.1038/s41598-023-35608-4.

2:Relationship between Chinese Herbal Medicine Use and Risk of Sjögren's Syndrome in Patients with Rheumatoid Arthritis: A Retrospective, Population-Based, Nested Case-Control Study.
Authors:Liao HH, Livneh H, Lin MC, Lu MC, Lai NS, Yen HR, Tsai TY
Institution:Graduate Institute of Chinese Medicine, School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404333, Taiwan.; Department of Nursing, Tzu Chi University of Science and Technology, Hualien 62247, Taiwan.
Journal:Medicina (Kaunas). 2023 Mar 30;59(4):683. doi: 10.3390/medicina59040683.

3:The Interplay between Cardiovascular Risk, Cardiovascular Events, and Disease Activity in Primary Sjögren's Syndrome: Is Uric Acid the Missing Link?
Authors:Alunno A, Carubbi F, Mariani FM, Martini C, Campanozzi E, Ferri C
Institution:Internal Medicine and Nephrology Division, Department of Life, Health & Environmental Sciences, San Salvatore Hospital, University of L'Aquila, ASL 1 Avezzano-Sulmona-L'Aquila, 67100 L'Aquila, Italy.
Journal:Nutrients. 2023 Mar 23;15(7):1563. doi: 10.3390/nu15071563.

4:Coping strategies, illness perceptions, and relationship dynamics contribute to female sexual function and sexual distress in Sjögren's syndrome.
Authors:McCready JL, Deary V, Collins TL, Lendrem DW, Hackett KL
Institution:Department of Social Work, Education and Community Wellbeing, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, NE7 7XA, United Kingdom.
Journal:J Sex Med. 2023 May 26;20(6):781-791. doi: 10.1093/jsxmed/qdad044.

5:Oral Health and Oral Health-Related Quality of Life in Patients with Primary Sjögren's Syndrome.
Authors:Vujovic S, Desnica J, Stevanovic M, Mijailovic S, Vojinovic R, Selakovic D, Jovicic N, Rosic G, Milovanovic D
Institution:Department of Dentistry, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovi?a 69, 34000 Kragujevac, Serbia.; Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovi?a 69, 34000 Kragujevac, Serbia.
Journal:Medicina (Kaunas). 2023 Feb 27;59(3):473. doi: 10.3390/medicina59030473.

6:Exposure to environmental air pollutants as a risk factor for primary Sjögren's syndrome.
Authors:Ma KS, Wang LT, Chong W, Lin CL, Li H, Chen A, Wei JC
Institution:Department of Pediatrics, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Journal:Front Immunol. 2023 Feb 14;13:1044462. doi: 10.3389/fimmu.2022.1044462. eCollection 2022.

7:Pathogenesis and treatment of Sjogren's syndrome: Review and update.
Authors:Zhan Q, Zhang J, Lin Y, Chen W, Fan X, Zhang D
Institution:State Key Laboratory of Biotherapy and Cancer Center, Department of Biotherapy, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Journal:Front Immunol. 2023 Feb 2;14:1127417. doi: 10.3389/fimmu.2023.1127417. eCollection 2023.

8:Sjögren's syndrome with and without neurological involvement.
Authors:Seeliger T, Kramer E, Konen FF, Zehrfeld N, Beider S, Prenzler NK, Gödecke V, Witte T, Skripuletz T, Ernst D
Institution:Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.
Journal:J Neurol. 2023 Jun;270(6):2987-2996. doi: 10.1007/s00415-023-11613-5. Epub 2023 Feb 18.

9:A multi-center, open-label, randomized study to explore efficacy and safety of baricitinib in active primary Sjogren's syndrome patients.
Authors:Bai W, Yang F, Xu H, Wei W, Li H, Zhang L, Zhao Y, Shi X, Zhang Y, Zeng X, Leng X
Institution:Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Journal:Trials. 2023 Feb 15;24(1):112. doi: 10.1186/s13063-023-07087-5.

10:Vitamin D and Sjögren's Disease: Revealing the Connections-A Systematic Review and Meta-Analysis.
Authors:Radić M, Kolak E, Đogaš H, Gelemanović A, Bučan Nenadić D, Vučković M, Radić J
Institution:Internal Medicine Department, Rheumatology, Allergology, and Clinical Immunology Division, University Hospital of Split, 21000 Split, Croatia.; Department of Internal Medicine, School of Medicine, University of Split, 21000 Split, Croatia.
Journal:Nutrients. 2023 Jan 18;15(3):497. doi: 10.3390/nu15030497.

11:Renal involvement in Sjőgren's syndrome: predictors and impact on patient outcomes.
Authors:Chatterjee R, Balakrishnan A, Kharbanda R, Rathore U, Gupta L, Misra DP, Agarwal V, Aggarwal A, Lawrence A
Institution:Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, 226014, India.
Journal:Rheumatol Int. 2023 Jul;43(7):1297-1306. doi: 10.1007/s00296-022-05242-w. Epub 2023 Jan 18.

12:Pulmonary fibrosis in primary Sjögren syndrome: computed tomography, clinical features, and associated clinical factors.
Authors:Li D, Li H, Wang Y, Zhu T
Institution:Department of Radiology, Fuyong People?s Hospital of Shenzhen Bao?an, Shenzhen, China; Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Journal:Pol Arch Intern Med. 2023 Feb 27;133(2):16394. doi: 10.20452/pamw.16394. Epub 2023 Jan 4.

13:Menstrual and Reproductive Characteristics of Patients with Primary Sjogren's Syndrome: A 7-year Single-center Retrospective Study.
Authors:Zhu YZ, Zhong JX, Dong LL
Institution:Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Journal:Curr Med Sci. 2023 Feb;43(1):139-145. doi: 10.1007/s11596-022-2675-4. Epub 2022 Dec 21.

14:Risk factors for primary Sjögren's Syndrome: a systematic review and meta-analysis.
Authors:Jin L, Dai M, Li C, Wang J, Wu B
Institution:Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, No. 6, Pan Xi Qi Zhi Road, Jiangbei District, Chongqing, 400021, China.
Journal:Clin Rheumatol. 2023 Feb;42(2):327-338. doi: 10.1007/s10067-022-06474-8. Epub 2022 Dec 19.

15:Sjögren syndrome.
Authors:Brito-Zerón P, Retamozo S, Ramos-Casals M
Institution:Research and Innovation Group in Autoimmune Diseases, Sanitas Digital Hospital, Hospital-CIMA-Centre Medic Milenium Balmes Sanitas, Barcelona, Espana; Linea de investigacion de Sjogren del Grupo de Enfermedades Autoinmunes Sistemicas (GEAS), Sociedad Espanola de Medicina Interna (SEMI), Espana.; Linea de investigacion de Sjogren del Grupo de Enfermedades Autoinmunes Sistemicas (GEAS), Sociedad Espanola de Medicina Interna (SEMI), Espana; Departament de Medicina, Universitat de Barcelona, Barcelona, Espana; Servicio de Enfermedades Autoinmunes, Institut Clinic de Medicina i Dermatologia (ICMiD), Hospital Clinic, Barcelona, Espana. Electronic address:
Journal:Med Clin (Barc). 2023 Feb 24;160(4):163-171. doi: 10.1016/j.medcli.2022.10.007. Epub 2022 Dec 15.

16:Long-term risk of heart failure and other adverse cardiovascular outcomes in primary Sjögren's syndrome.
Authors:Sun G, Fosbøl EL, Yafasova A, Faurschou M, Lindhardsen J, Torp-Pedersen C, Køber L, Butt JH
Institution:Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Journal:J Intern Med. 2023 Apr;293(4):457-469. doi: 10.1111/joim.13595. Epub 2022 Dec 11.

17:Clinical features and high-risk indicators of central nervous system involvement in primary Sjögren's syndrome.
Authors:Fan W, Par-Young J, Li K, Zhang Y, Xiao P, Hua L, Leng L, Chen X, Bucala R
Institution:Department of Rheumatology and Immunology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen Medical College, Xiamen, 361021, China.; Department of Internal Medicine, Section of Rheumatology, Allergy & Immunology, Yale University School of Medicine, New Haven, CT, 06520, USA.
Journal:Clin Rheumatol. 2023 Feb;42(2):443-451. doi: 10.1007/s10067-022-06448-w. Epub 2022 Nov 19.

18:Prevalence of hearing loss in patients with Sjögren syndrome: a systematic review and meta-analysis.
Authors:Paraschou V, Partalidou S, Siolos P, Papadopoulou Z, Chaitidis N
Institution:Hellenic Police Medical Center, Thessaloniki, Greece.; 2nd Internal Medicine Department, 424 General Military Hospital of Thessaloniki, Thessaloniki, Greece.
Journal:Rheumatol Int. 2023 Feb;43(2):233-244. doi: 10.1007/s00296-022-05235-9. Epub 2022 Oct 28.

19:Short-term results of a pulsed therapy with hydrocortisone eye drops to treat moderate to severe dry eye in primary Sjögren syndrome patients.
Authors:Menchini M, Sartini F, Figus M, Gabbriellini G
Institution:Ophthalmology, Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, Via Savi, 10, 56126, Pisa, Italy.
Journal:Graefes Arch Clin Exp Ophthalmol. 2023 Apr;261(4):1029-1036. doi: 10.1007/s00417-022-05840-1. Epub 2022 Oct 4.

20:Primary Sjögren syndrome-related peripheral neuropathy: A systematic review and meta-analysis.
Authors:Liampas A, Parperis K, Erotocritou MF, Nteveros A, Papadopoulou M, Moschovos C, Akil M, Coaccioli S, Hadjigeorgiou GM, Hadjivassiliou M, Zis P
Institution:Medical School, University of Cyprus, Nicosia, Cyprus.
Journal:Eur J Neurol. 2023 Jan;30(1):255-265. doi: 10.1111/ene.15555. Epub 2022 Sep 23.

21:Chemosensory dysfunction in primary Sjögren's syndrome: a topical review.
Authors:Foguem C, Seror R, Gosset M
Institution:Auban Moet-Centre Hospitalier d'Epernay, Adresse:137, Rue de l'Hopital, 51200, Epernay, France.; Service de Medecine Bucco-Dentaire, AP-HP, Hopital Charles Foix, 94200, Ivry/seine, France.
Journal:Clin Rheumatol. 2023 Jan;42(1):1-14. doi: 10.1007/s10067-022-06359-w. Epub 2022 Sep 5.

22:Peripheral nervous system involvement in Sjogren's syndrome and its impact on quality of life.
Authors:S B, Naidu G, Sharma A, Minz RW, Gupta A, Baishya J
Institution:Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.; Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Journal:Clin Exp Med. 2023 Jun;23(2):539-545. doi: 10.1007/s10238-022-00837-w. Epub 2022 Jun 6.

23:Abatacept ameliorates both glandular and extraglandular involvements in patients with Sjögren's syndrome associated with rheumatoid arthritis: Findings from an open-label, multicentre, 1-year, prospective study: The ROSE (Rheumatoid Arthritis with Orencia Trial Toward Sjögren's Syndrome Endocrinopathy) and ROSE II trials.
Authors:Tsuboi H, Toko H, Honda F, Abe S, Takahashi H, Yagishita M, Hagiwara S, Ohyama A, Kondo Y, Nakano K, Tanaka Y, Shimizu T, Nakamura H, Kawakami A, Fujieda Y, Atsumi T, Suzuki Y, Kawano M, Nishina N, Kaneko Y, Takeuchi T, Kobayashi H, Takei M, Ogasawara M, Tamura N, Takasaki Y, Yokota K, Akiyama Y, Mimura T, Murakami K, Mimori T, Ohshima S, Azuma N, Sano H, Nishiyama S, Matsumoto I, Sumida T
Institution:Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Journal:Mod Rheumatol. 2023 Jan 3;33(1):160-168. doi: 10.1093/mr/roac011.

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