Parkinson's Disease
January 2024 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Dietary flavonoids may have a protective and therapeutic effect in Parkinson disease: A systematic review.
Authors:González-May CA, Barradas-Castillo MDR, Perera-Rios JH, Gallegos-Tintoré S, Pérez-Izquierdo O, Aranda-González II
Institution:Facultad de Medicina, Universidad Autonoma de Yucatan, Centro, 97000, Merida, Yucatan, Mexico. Electronic address:
Journal:Nutr Res. 2024 Jan;121:39-50. doi: 10.1016/j.nutres.2023.10.004. Epub 2023 Nov 3.

2:Parkinson's Disease: Advances in Treatment and the Syntheses of Various Classes of Pharmaceutical Drug Substances.
Authors:Hill DR, Huters AD, Towne TB, Reddy RE, Fogle JL, Voight EA, Kym PR
Journal:Chem Rev. 2023 Dec 13;123(23):13693-13712. doi: 10.1021/acs.chemrev.3c00479. Epub 2023 Nov 17.

3:Cognitive Impairment in Parkinson's Disease: An Updated Overview Focusing on Emerging Pharmaceutical Treatment Approaches.
Authors:Degirmenci Y, Angelopoulou E, Georgakopoulou VE, Bougea A
Institution:Department of Neurology, School of Medicine, Istanbul Health and Technology University, 34093 Istanbul, Turkey.; 1st Department of Neurology, Medical School, National and Kapodistrian University of Athens, Eginition Hospital, 11528 Athens, Greece.
Journal:Medicina (Kaunas). 2023 Oct 1;59(10):1756. doi: 10.3390/medicina59101756.

4:Effects of HiBalance training program on physical function of individuals with idiopathic Parkinson disease: a systematic review and meta-analysis.
Authors:Malmir K, Ashrafganjooie M
Institution:School of Rehabilitation, Physical Therapy Department, Tehran University of Medical Sciences, P. O. Box: 113635-1683, Tehran, Iran.; School of Paramedical Sciences, Physical Therapy Department, Kerman University of Medical Sciences, Kerman, Iran.
Journal:Eur Geriatr Med. 2023 Dec;14(6):1273-1288. doi: 10.1007/s41999-023-00860-4. Epub 2023 Sep 12.

5:Effectiveness of Botulinum Toxin on Hand Tremor Intensity and Upper Limb Function in Patients with Parkinson's Disease: Results of a Systematic Review.
Authors:Eslamian F, Dolatkhah N, Fallah L, Jahanjoo F, Toopchizadeh V, Talebi M
Institution:Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Journal:Tremor Other Hyperkinet Mov (N Y). 2023 Aug 24;13:27. doi: 10.5334/tohm.773. eCollection 2023.

6:Continuous subcutaneous levodopa-carbidopa for the treatment of advanced Parkinson's disease: is it an improvement on other delivery?
Authors:Doggrell SA
Institution:School of Pharmacy and Medical Sciences, Griffith University, Gold Coast Campus, Gold Coast, Queensland, Australia.
Journal:Expert Opin Drug Deliv. 2023 Jul-Dec;20(9):1189-1199. doi: 10.1080/17425247.2023.2253146. Epub 2023 Sep 10.

7:Pharmacological and Non-Pharmacological Treatments for Depression in Parkinson's Disease: An Updated Review.
Authors:Angelopoulou E, Stanitsa E, Karpodini CC, Bougea A, Kontaxopoulou D, Fragkiadaki S, Koros C, Georgakopoulou VE, Fotakopoulos G, Koutedakis Y, Piperi C, Papageorgiou SG
Institution:1st Department of Neurology, Medical School, National and Kapodistrian University of Athens, Eginition Hospital, 11528 Athens, Greece.
Journal:Medicina (Kaunas). 2023 Aug 12;59(8):1454. doi: 10.3390/medicina59081454.

8:The pharmacological management of the behavioral aspects of Parkinson's disease: an update.
Authors:Campagnolo M, Emmi A, Biundo R, Fiorenzato E, Batzu L, Chaudhuri KR, Antonini A
Institution:Parkinson's Disease and Movement Disorders Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, University of Padova, Padova, Italy.
Journal:Expert Opin Pharmacother. 2023 Sep-Dec;24(15):1693-1701. doi: 10.1080/14656566.2023.2240228. Epub 2023 Jul 26.

9:Spinal Cord Stimulation for Gait Disorders in Parkinson's Disease and Atypical Parkinsonism: A Systematic Review of Preclinical and Clinical Data.
Authors:Ciocca M, Seemungal BM, Tai YF
Institution:Department of Brain Sciences, Imperial College London, London, UK. Electronic address:
Journal:Neuromodulation. 2023 Oct;26(7):1339-1361. doi: 10.1016/j.neurom.2023.06.003. Epub 2023 Jul 13.

10:Botulinum toxin in the management of parkinsonian disorders.
Authors:Grippe T, Chen R
Institution:Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada; Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Neuroscience Graduate Program, Federal University of Minas Gerais, Belo Horizonte, Brazil; Krembil Brain Institute, Toronto, Ontario, Canada; Divison of Neurology, Department of Medicine, University of Toronto, Canada.; Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada; Divison of Neurology, Department of Medicine, University of Toronto, Canada. Electronic address:
Journal:Toxicon. 2023 Aug 15;232:107209. doi: 10.1016/j.toxicon.2023.107209. Epub 2023 Jul 8.

11:Parkinson's and the couple relationship: a qualitative meta-synthesis.
Authors:Glover L, Dixon C, Kobylecki C, Eccles FJR
Institution:Lancaster University, Health Innovation One, Sir John Fisher Drive, Lancaster University, Lancaster, UK.
Journal:Aging Ment Health. 2023 Nov-Dec;27(12):2420-2429. doi: 10.1080/13607863.2023.2227119. Epub 2023 Jun 24.

12:Natural Products as the Potential to Improve Alzheimer's and Parkinson's Disease.
Authors:Kim SW, Lee JH, Kim B, Yang G, Kim JU
Institution:College of Korea Medicine, Woosuk University, Jeonju-si 54986, Republic of Korea.
Journal:Int J Mol Sci. 2023 May 16;24(10):8827. doi: 10.3390/ijms24108827.

13:Does Exercise Attenuate Disease Progression in People With Parkinson's Disease? A Systematic Review With Meta-Analyses.
Authors:Li JA, Loevaas MB, Guan C, Goh L, Allen NE, Mak MKY, Lv J, Paul SS
Institution:Discipline of Movement Sciences, School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Journal:Neurorehabil Neural Repair. 2023 May;37(5):328-352. doi: 10.1177/15459683231172752. Epub 2023 May 11.

14:Inhaled levodopa for threatening impending OFF episodes in managing Parkinson's disease.
Authors:Jost WH, Kulisevsky J, LeWitt PA
Institution:Parkinson-Klinik Ortenau, Kreuzbergstr. 12-16, 77709, Wolfach, Germany.; Wayne State University School of Medicine (Sastry Foundation Endowed Chair in Neurology and Henry Ford Hospital), Detroit, MI, 48201, USA.
Journal:J Neural Transm (Vienna). 2023 Jun;130(6):821-826. doi: 10.1007/s00702-023-02636-3. Epub 2023 Apr 23.

15:Rehabilitative interventions for impaired handwriting in people with Parkinson's disease: a scoping review.
Authors:Gardoni A, Sarasso E, Agosta F, Filippi M, Corbetta D
Institution:Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Department of Rehabilitation and Functional Recovery, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Journal:Neurol Sci. 2023 Aug;44(8):2667-2677. doi: 10.1007/s10072-023-06752-6. Epub 2023 Mar 25.

16:Recent Advances in the Treatment of Genetic Forms of Parkinson's Disease: Hype or Hope?
Authors:Cavallieri F, Cury RG, Guimarães T, Fioravanti V, Grisanti S, Rossi J, Monfrini E, Zedde M, Di Fonzo A, Valzania F, Moro E
Institution:Neurology Unit, Neuromotor & Rehabilitation Department, Azienda USL-IRCCS of Reggio Emilia, 42123 Reggio Emilia, Italy.; Division of Neurology, CHU of Grenoble, Grenoble Institute of Neurosciences, Grenoble Alpes University, 38700 Grenoble, France.
Journal:Cells. 2023 Feb 27;12(5):764. doi: 10.3390/cells12050764.

17:Efficacy of Specific Trunk Exercises in the Balance Dysfunction of Patients with Parkinson's Disease: A Systematic Review and Meta-Analysis.
Authors:López-Liria R, Vega-Tirado S, Valverde-Martínez MÁ, Calvache-Mateo A, Martínez-Martínez AM, Rocamora-Pérez P
Institution:Health Research Centre, Department of Nursing, Physiotherapy and Medicine, University of Almeria, Carretera del Sacramento s/n, 04120 La Canada de San Urbano, Almeria, Spain.
Journal:Sensors (Basel). 2023 Feb 6;23(4):1817. doi: 10.3390/s23041817.

18:Botulinum Toxin Treatment of Motor Disorders in Parkinson Disease-A Systematic Review.
Authors:Jabbari B, Comtesse SM
Institution:Department of Neurology, Yale University School of Medicine, New Haven, CT 06519, USA.; Faculty of Medicine, Goethe University, 60590 Frankfurt am Main, Germany.
Journal:Toxins (Basel). 2023 Jan 17;15(2):81. doi: 10.3390/toxins15020081.

19:Pros and cons for statins use and risk of Parkinson's disease: An updated perspective.
Authors:Al-Kuraishy HM, Al-Gareeb AI, Alexiou A, Papadakis M, Alsayegh AA, Almohmadi NH, Saad HM, Batiha GE
Institution:Department of Clinical Pharmacology and Medicine, College of Medicine, ALmustansiriyia University, Baghdad, Iraq.; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.
Journal:Pharmacol Res Perspect. 2023 Apr;11(2):e01063. doi: 10.1002/prp2.1063.

20:Systematic review and meta-analysis of the quality-of-life of patients with Parkinson's disease.
Authors:Hoseinipalangi Z, Pashazadeh Kan F, Hosseinifard H, Doustmehraban M, Masoumi M, Rafiei S, Barmayoon P, Ahmadi N, Dehnad A, Eshtod H, Asl MT, Sadat Hoseini B, Nasiri M, Arian M, Aghalou S, Ghashghaee A
Institution:School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran.; Social Determinants of |Health Research Center, Qazvin University of Medical Sciences, Qazvin, Islamic Republic of Iran.
Journal:East Mediterr Health J. 2023 Jan 19;29(1):63-70. doi: 10.26719/emhj.23.013.

21:Sleep and wakefulness disturbances in Parkinson's disease: A meta-analysis on prevalence and clinical aspects of REM sleep behavior disorder, excessive daytime sleepiness and insomnia.
Authors:Maggi G, Vitale C, Cerciello F, Santangelo G
Institution:Department of Psychology, University of Campania 'Luigi Vanvitelli', Caserta, Italy. Electronic address:
Journal:Sleep Med Rev. 2023 Apr;68:101759. doi: 10.1016/j.smrv.2023.101759. Epub 2023 Jan 16.

22:An Apple a Day to Keep the Parkinson's Disease Doctor Away?
Authors:Bloem BR, Post E, Hall DA
Institution:Department of Neurology, Centre of Expertise for Parkinson & Movement Disorders, Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.; Department of Neurological Sciences, Rush University, Chicago, IL, USA.
Journal:Ann Neurol. 2023 Apr;93(4):681-685. doi: 10.1002/ana.26612. Epub 2023 Feb 9.

23:Premotor, nonmotor and motor symptoms of Parkinson's Disease: A new clinical state of the art.
Authors:Leite Silva ABR, Gonçalves de Oliveira RW, Diógenes GP, de Castro Aguiar MF, Sallem CC, Lima MPP, de Albuquerque Filho LB, Peixoto de Medeiros SD, Penido de Mendonça LL, de Santiago Filho PC, Nones DP, da Silva Cardoso PMM, Ribas MZ, Galvão SL, Gomes GF, Bezerra de Menezes AR, Dos Santos NL, Mororó VM, Duarte FS, Dos Santos JCC
Institution:Centro Universitario Christus, UNICHRISTUS, Fortaleza, CE, Brazil.; Centro Universitario Christus, UNICHRISTUS, Fortaleza, CE, Brazil; Universidade Federal do Ceara, Fortaleza, CE, Brazil; Programa de Pos-graduacao em Ciencias Morfofuncionais, Departamento de Morfologia, Universidade Federal do Ceara, Fortaleza, CE, Brazil. Electronic address:
Journal:Ageing Res Rev. 2023 Feb;84:101834. doi: 10.1016/j.arr.2022.101834. Epub 2022 Dec 26.

24:Efficacy and safety of non-ergot dopamine-receptor agonists as an adjunct to levodopa in advanced Parkinson's disease: A network meta-analysis.
Authors:Chen XT, Zhang Q, Wen SY, Chen FF, Zhou CQ
Institution:Department of Neurology, Bishan Hospital of Chongqing Medical University, Chongqing, China.
Journal:Eur J Neurol. 2023 Mar;30(3):762-773. doi: 10.1111/ene.15635. Epub 2022 Nov 30.

25:Swallowing outcomes in dysphagia interventions in Parkinson's disease: a scoping review.
Authors:Hirschwald J, Hofacker J, Duncan S, Walshe M
Institution:Clinical Speech and Language Studies, Trinity College Dublin, Dublin, Ireland; Clinical Speech and Language Studies, Trinity College Dublin, Dublin, Ireland.
Journal:BMJ Evid Based Med. 2023 Apr;28(2):111-118. doi: 10.1136/bmjebm-2022-112082. Epub 2022 Nov 11.

26:Exercise for Depressive Symptoms in Parkinson Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Authors:Feller D, Fox I, Gozzer P, Trentin F, Papola D
Institution:Provincial Agency for Health of the Autonomous Province of Trento, Trento, Italy; Centre of Higher Education for Health Sciences of Trento, Trento, Italy. Electronic address:; WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Department of Neuroscience, Biomedicine, and Movement Science, Section of Psychiatry, University of Verona, Verona, Italy.
Journal:Arch Phys Med Rehabil. 2023 Feb;104(2):331-339. doi: 10.1016/j.apmr.2022.07.021. Epub 2022 Aug 27.

27:Deep Brain Stimulation in Parkinson Disease: A Meta-analysis of the Long-term Neuropsychological Outcomes.
Authors:Bucur M, Papagno C
Institution:Center for Mind/Brain Sciences (CIMeC), University of Trento, Trento, Italy.
Journal:Neuropsychol Rev. 2023 Jun;33(2):307-346. doi: 10.1007/s11065-022-09540-9. Epub 2022 Mar 23.

28:Opicapone for the treatment of Parkinson's disease: a review.
Authors:Feldman M, Margolesky J
Institution:Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Journal:Int J Neurosci. 2023 May;133(5):532-543. doi: 10.1080/00207454.2021.1929217. Epub 2021 Jun 1.

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