Atrial Fibrillation
July 2023 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Atrial Fibrillation abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Atrial Fibrillation. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Atrial Fibrillation. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Atrial Fibrillation every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Silent cerebral lesions following catheter ablation for atrial fibrillation: a state-of-the-art review.
Authors:Calvert P, Kollias G, Pürerfellner H, Narasimhan C, Osorio J, Lip GYH, Gupta D
Institution:Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK.
Journal:Europace. 2023 Jun 2;25(6):euad151. doi: 10.1093/europace/euad151.

2:Oral anticoagulant switching in patients with atrial fibrillation: a scoping review.
Authors:Adelakun AR, Turgeon RD, De Vera MA, McGrail K, Loewen PS
Institution:Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada
Journal:BMJ Open. 2023 Apr 25;13(4):e071907. doi: 10.1136/bmjopen-2023-071907.

3:Challenges of Anticoagulant Therapy in Atrial Fibrillation-Focus on Gastrointestinal Bleeding.
Authors:Scridon A, Balan AI
Institution:Physiology Department, University of Medicine, Pharmacy, Science and Technology 'George Emil Palade' of Targu Mure?, 540142 Targu Mure?, Romania.
Journal:Int J Mol Sci. 2023 Apr 7;24(8):6879. doi: 10.3390/ijms24086879.

4:Approach to atrial fibrillation: Essentials for primary care.
Authors:Bell A, Andrade JG, Macle L, Connelly KA, LaBine L, Singer AG
Institution:Assistant Professor in the Department of Family and Community Medicine at the University of Toronto in Ontario and served as a Canadian Cardiovascular Society (CCS) atrial fibrillation guideline panel member.; Associate Professor in the Department of Family Medicine in the Max Rady College of Medicine of the Rady Faculty of Health Sciences at the University of Manitoba.
Journal:Can Fam Physician. 2023 Apr;69(4):245-256. doi: 10.46747/cfp.6904245.

5:Oral Anticoagulation in Patients With Advanced Chronic Kidney Disease and Atrial Fibrillation: Beyond Anticoagulation.
Authors:Dhaese SAM, De Vriese AS
Institution:Division of Nephrology and Infectious Diseases, AZ Sint-Jan Brugge, Brugge, Belgium, and Department of Internal Medicine, Ghent University, Ghent, Belgium. Electronic address:
Journal:Mayo Clin Proc. 2023 May;98(5):750-770. doi: 10.1016/j.mayocp.2023.01.007. Epub 2023 Apr 5.

6:Effects of Oral Inflammatory Diseases and Oral Hygiene on Atrial Fibrillation: A Systematic Review.
Authors:Zhang Z, Chen F, Gao X, Xiao B, Liu F, Lu J
Institution:The Second Department of Cardiovascular Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Journal:Int J Clin Pract. 2023 Mar 27;2023:1750981. doi: 10.1155/2023/1750981. eCollection 2023.

7:Association of type 1 diabetes mellitus and risk of atrial fibrillation: Systematic review and meta-analysis.
Authors:Guo S, Huang Y, Liu X, Ma J, Zhu W
Institution:Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China. Electronic address:
Journal:Diabetes Res Clin Pract. 2023 May;199:110629. doi: 10.1016/j.diabres.2023.110629. Epub 2023 Mar 21.

8:Increased major bleeding incidence in atrial fibrillation patients with apixaban: a review of Japanese post-marketing surveillance studies of direct oral anticoagulants.
Authors:Sairaku A, Nakano Y
Institution:Department of Cardiology, Cardiovascular Center, National Hospital Organization Higashihiroshima Medical Center, 513 Jike, Saijo-cho, 739-0041, Higashihiroshima, Japan.; Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Journal:Eur J Clin Pharmacol. 2023 May;79(5):579-588. doi: 10.1007/s00228-023-03471-x. Epub 2023 Mar 14.

9:Drug-drug interactions with direct oral anticoagulants for the prevention of ischemic stroke and embolism in atrial fibrillation: a narrative review of adverse events.
Authors:Stöllberger C, Schneider B, Finsterer J
Institution:Klinik Landstrasse, Wien, Austria.
Journal:Expert Rev Clin Pharmacol. 2023 Apr;16(4):313-328. doi: 10.1080/17512433.2023.2187376. Epub 2023 Mar 7.

10:Effect of Prolonged and Substantial Weight Loss on Incident Atrial Fibrillation: A Systematic Review and Meta-Analysis.
Authors:Pontiroli AE, Centofanti L, Le Roux CW, Magnani S, Tagliabue E, Folli F
Institution:Dipartimento di Scienze della Salute, Universita degli Studi di Milano, 20133 Milan, Italy.
Journal:Nutrients. 2023 Feb 14;15(4):940. doi: 10.3390/nu15040940.

11:Heart failure with preserved ejection fraction and atrial fibrillation: recent advances and open questions.
Authors:Fauchier L, Bisson A, Bodin A
Institution:Service de Cardiologie, Centre Hospitalier Universitaire Trousseau Et Faculte de Medecine, Universite Francois Rabelais, 37044, Tours, France.
Journal:BMC Med. 2023 Feb 13;21(1):54. doi: 10.1186/s12916-023-02764-3.

12:Current Evidence on Prevention of Atrial Fibrillation: Modifiable Risk Factors and the Effects of Risk Factor Intervention.
Authors:Akboga MK, Inanc IH, Keskin M, Sabanoglu C, Gorenek B
Institution:From the Department of Cardiology, Gazi University Faculty of Medicine, Ankara, Turkey.; Department of Cardiology, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
Journal:Cardiol Rev. 2023 Mar-Apr 01;31(2):70-79. doi: 10.1097/CRD.0000000000000426. Epub 2021 Oct 20.

13:Atrial fibrillation ablation as first-line therapy for patients with heart failure with reduced ejection fraction (HFrEF): evaluating the impact on patient survival.
Authors:Younes H, Noujaim C, Mekhael M, Chouman N, Assaf A, Kreidieh O, Lim C, Marrouche N, Donnellan E
Institution:Tulane Research and Innovation for Arrhythmia Discoveries- TRIAD Center, Tulane University School of Medicine, New Orleans, LA, USA.
Journal:Expert Rev Cardiovasc Ther. 2023 Feb;21(2):111-121. doi: 10.1080/14779072.2023.2172402. Epub 2023 Feb 10.

14:Blood pressure, hypertension and the risk of atrial fibrillation: a systematic review and meta-analysis of cohort studies.
Authors:Aune D, Mahamat-Saleh Y, Kobeissi E, Feng T, Heath AK, Janszky I
Institution:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, Paddington, London, W2 1PG, UK.; Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
Journal:Eur J Epidemiol. 2023 Feb;38(2):145-178. doi: 10.1007/s10654-022-00914-0. Epub 2023 Jan 10.

15:Epidemiology and modifiable risk factors for atrial fibrillation.
Authors:Elliott AD, Middeldorp ME, Van Gelder IC, Albert CM, Sanders P
Institution:Centre for Heart Rhythm Disorders, University of Adelaide, Adelaide, South Australia, Australia.
Journal:Nat Rev Cardiol. 2023 Jun;20(6):404-417. doi: 10.1038/s41569-022-00820-8. Epub 2023 Jan 4.

16:Weight loss and atrial fibrillation: a review.
Authors:Tomaiko-Clark E, Husain F, Su W
Institution:University of Arizona College of Medicine-Phoenix.
Journal:Curr Opin Cardiol. 2023 Jan 1;38(1):6-10. doi: 10.1097/HCO.0000000000001004. Epub 2022 Nov 2.

17:Risk and benefit of extrapulmonary vein ablation in atrial fibrillation.
Authors:Liao Y, Katrapati P, Bai R
Institution:Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Division of Cardiology, Banner University Medical Center, University of Arizona, School of Medicine, Phoenix, Arizona, USA.
Journal:Curr Opin Cardiol. 2023 Jan 1;38(1):1-5. doi: 10.1097/HCO.0000000000001002. Epub 2022 Oct 20.

18:Alcohol Consumption and Atrial Arrhythmia Recurrence After Atrial Fibrillation Ablation: A Systematic Review and Meta-analysis.
Authors:Grindal AW, Sparrow RT, McIntyre WF, Conen D, Healey JS, Wong JA
Institution:Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Population Health Research Institute, Hamilton, Ontario, Canada. Electronic address:
Journal:Can J Cardiol. 2023 Mar;39(3):266-273. doi: 10.1016/j.cjca.2022.12.010. Epub 2022 Dec 19.

19:Atrial fibrillation and stroke.
Authors:Choi SE, Sagris D, Hill A, Lip GYH, Abdul-Rahim AH
Institution:Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK.
Journal:Expert Rev Cardiovasc Ther. 2023 Jan;21(1):35-56. doi: 10.1080/14779072.2023.2160319. Epub 2023 Jan 8.

20:Atrial Fibrillation Detection and Management in Hypertension.
Authors:Gawałko M, Linz D
Institution:First Department of Cardiology, Medical University of Warsaw, Poland (M.G.).; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (D.L.).
Journal:Hypertension. 2023 Mar;80(3):523-533. doi: 10.1161/HYPERTENSIONAHA.122.19459. Epub 2022 Dec 15.

21:Omega-3 fatty acids and atrial fibrillation.
Authors:Huh JH, Jo SH
Institution:Division of Endocrinology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.; Division of Cardiology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.
Journal:Korean J Intern Med. 2023 May;38(3):282-289. doi: 10.3904/kjim.2022.266. Epub 2022 Dec 14.

22:Direct Oral Anticoagulants: An Updated Systematic Review of Their Clinical Pharmacology and Clinical Effectiveness and Safety in Patients With Nonvalvular Atrial Fibrillation.
Authors:Bortman LV, Mitchell F, Naveiro S, Pérez Morales J, Gonzalez CD, Di Girolamo G, Giorgi MA
Institution:Department of Pharmacology, School of Medicine, Instituto Universitario CEMIC, Buenos Aires, Argentina.
Journal:J Clin Pharmacol. 2023 Apr;63(4):383-396. doi: 10.1002/jcph.2184. Epub 2023 Jan 29.

23:Left atrial appendage closure for stroke prevention in nonvalvular atrial fibrillation: A current overview.
Authors:Ueno H, Imamura T, Tanaka S, Fukuda N, Kinugawa K
Institution:Second Department of Internal Medicine, University of Toyama, Toyama, Japan. Electronic address:
Journal:J Cardiol. 2023 May;81(5):420-428. doi: 10.1016/j.jjcc.2022.11.006. Epub 2022 Nov 15.

24:Mechanisms and Clinical Manifestations of Cognitive Decline in Atrial Fibrillation Patients: Potential Implications for Preventing Dementia.
Authors:Blum S, Conen D
Institution:Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada. Electronic address:
Journal:Can J Cardiol. 2023 Feb;39(2):159-171. doi: 10.1016/j.cjca.2022.10.013. Epub 2022 Oct 15.

25:Risk and Management of Bleeding Complications with Direct Oral Anticoagulants in Patients with Atrial Fibrillation and Venous Thromboembolism: a Narrative Review.
Authors:Ballestri S, Romagnoli E, Arioli D, Coluccio V, Marrazzo A, Athanasiou A, Di Girolamo M, Cappi C, Marietta M, Capitelli M
Institution:Internal Medicine Unit, Hospital of Pavullo-Department of Internal Medicine, Azienda USL, 41126, Pavullo, Modena, Italy.
Journal:Adv Ther. 2023 Jan;40(1):41-66. doi: 10.1007/s12325-022-02333-9. Epub 2022 Oct 16.

26:Comparison of catheter ablation and medical therapy for atrial fibrillation in heart failure patients: A meta-analysis of randomized controlled trials.
Authors:Şaylık F, Çınar T, Akbulut T, Hayıroğlu Mİ
Institution:Health Sciences University, Van Training and Research Hospital, Van, Turkey.; Health Sciences University, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
Journal:Heart Lung. 2023 Jan-Feb;57:69-74. doi: 10.1016/j.hrtlng.2022.08.012. Epub 2022 Sep 7.

27:Neuromodulation therapy for atrial fibrillation.
Authors:Karatela MF, Fudim M, Mathew JP, Piccini JP
Institution:Cardiac Electrophysiology Section, Duke Heart Center and Department of Medicine, Duke University Medical Center, Durham, North Carolina; Duke Clinical Research Institute, Durham, North Carolina. Electronic address:
Journal:Heart Rhythm. 2023 Jan;20(1):100-111. doi: 10.1016/j.hrthm.2022.08.011. Epub 2022 Aug 18.

28:Comparing the efficacy of catheter ablation strategies for persistent atrial fibrillation: a Bayesian analysis of randomized controlled trials.
Authors:Wu S, Li H, Yi S, Yao J, Chen X
Institution:Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.; People's Hospital of Shizhong District, Zaozhuang, China.
Journal:J Interv Card Electrophysiol. 2023 Apr;66(3):757-770. doi: 10.1007/s10840-022-01246-5. Epub 2022 Jul 4.

29:Innovations in atrial fibrillation ablation.
Authors:Kim JA, Khan K, Kherallah R, Khan S, Kamat I, Ulhaq O, Marashly Q, Chelu MG
Institution:Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA.; Division of Cardiology, Baylor College of Medicine, 7200 Cambridge Suite A6.137, Houston, TX, MS: BCM621, USA.
Journal:J Interv Card Electrophysiol. 2023 Apr;66(3):737-756. doi: 10.1007/s10840-022-01215-y. Epub 2022 Apr 11.

30:The information needs of patients with atrial fibrillation: A scoping review.
Authors:Woo BFY, Bulto LN, Hendriks JML, Lim TW, Tam WWS
Institution:Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Journal:J Clin Nurs. 2023 May;32(9-10):1521-1533. doi: 10.1111/jocn.15993. Epub 2021 Aug 12.

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