Meniere's Disease
July 2019 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Meniere's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Meniere's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Meniere's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Meniere's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Hypothyroidism is an independent risk factor for Meniere's disease: A population-based cohort study.
Authors:Lin WL, Chen CY, Hsu TY, Chen WK, Lin CL, Chen HC
Institution:Department of Emergency Medicine. Taiwan.
Journal:Medicine (Baltimore). 2019 Apr;98(15):e15166. doi: 10.1097/MD.0000000000015166.

2:The role of magnetic resonance imaging in Meniere disease: the current state of endolymphatic hydrops evaluation.
Authors:Loureiro RM, Sumi DV, Lemos MD, Tames HLVC, Gomes RLE, Daniel MM, Soares CR, Murakoshi RW, Funari MBG
Institution:Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil.
Journal:Einstein (Sao Paulo). 2019 Feb 25;17(1):eMD4743. doi: 10.31744/einstein_journal/2019MD4743.

3:Positive pressure device treatment for Meniere's disease: an overview of the current evidence and a meta-analysis.
Authors:Devantier L, Guldfred FL, Djurhuus BD, Handel MN, Schmidt JH, Hougaard DD, Edemann-Callesen H
Institution:Department of Clinical Medicine, Aarhus University, Noerrebrogade 44, building 10G, 2nd floor, 8000, Aarhus C, Denmark. 12, Holstebro, 7500, Denmark. Hospital, Lykkebaekvej 1, 4600, Koege, Denmark. Frederiksberg, Nordre Fasanvej 57, 2000, Frederiksberg, Denmark. Hospital, J. B. Winslows Vej 4, 5000, Odense C, Denmark. Southern Denmark, Campusvej 55, 5230, Odense, Denmark. University Hospital, Havrevangen 1, 9000, Aalborg, Denmark.
Journal:Eur Arch Otorhinolaryngol. 2019 May;276(5):1263-1273. doi: 10.1007/s00405-019-05359-y. Epub 2019 Feb 27.

4:The value of four stage vestibular hydrops grading and asymmetric perilymphatic enhancement in the diagnosis of Meniere's disease on MRI.
Authors:Bernaerts A, Vanspauwen R, Blaivie C, van Dinther J, Zarowski A, Wuyts FL, Vanden Bossche S, Offeciers E, Casselman JW, De Foer B
Institution:Department of Radiology, GZA Hospitals Antwerp, Oosterveldlaan 24, 2610, Wilrijk, Belgium. Wilrijk, Belgium. Wilrijk, Belgium. Wilrijk, Belgium. Wilrijk, Belgium. 10, Building N012, 2610, Wilrijk, Belgium. Belgium. Wilrijk, Belgium. Belgium. Belgium. Belgium.
Journal:Neuroradiology. 2019 Apr;61(4):421-429. doi: 10.1007/s00234-019-02155-7. Epub 2019 Feb 5.

5:Quantitative evaluation of endolymphatic hydrops with MRI through intravenous gadolinium administration and VEMP in unilateral definite Meniere's disease.
Authors:Guo P, Sun W, Shi S, Zhang F, Wang J, Wang W
Institution:NHC Key Laboratory of Hearing Medicine, Department of Otolaryngology, Eye Ear Nose & Throat Hospital Shanghai, Fudan University, 83 Fenyang Rd, Shanghai, 200031, People's Republic of China.; Department of Otolaryngology, Chongqing General Hospital, Chongqing, 400000, People's Republic of China.; Department of Radiology, Eye Ear Nose & Throat Hospital Shanghai, Shanghai, People's Republic of China.
Journal:Eur Arch Otorhinolaryngol. 2019 Apr;276(4):993-1000. doi: 10.1007/s00405-018-05267-7. Epub 2019 Jan 29.

6:Postoperative compensation after neurotomy in Meniere's disease: Retrospective study of 15 cases.
Authors:Lemnos L, Aubry K, Moreau JJ, Caire F, Salle H
Institution:Service de neurochirurgie, CHU de Limoges, 87000 Limoges, France. address:
Journal:Neurochirurgie. 2019 Feb;65(1):20-26. doi: 10.1016/j.neuchi.2018.11.002. Epub 2019 Jan 16.

7:Clinical features and management of Meniere's disease patients with drop attacks.
Authors:Wu Q, Li X, Sha Y, Dai C
Institution:Department of Otology and Skull Base Surgery, Hearing Research Key Lab of Health Ministry of China, Eye and Ear Nose and Throat Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China. Ministry of China, Eye and Ear Nose and Throat Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China. Xuzhou, China. Shanghai, China.
Journal:Eur Arch Otorhinolaryngol. 2019 Mar;276(3):665-672. doi: 10.1007/s00405-018-5260-5. Epub 2019 Jan 2.

8:Clinical Features and Endolymphatic Hydrops in Patients With MRI Evidence of Hydrops.
Authors:Shi S, Guo P, Li W, Wang W
Institution:1 ENT Institute and Otorhinolaryngology Department, Affiliated Eye and ENT Hospital, Fudan University, Shanghai, China.; 2 Key Laboratory of Hearing Medicine of National Health and Family Planning Commission (NHFPC), Fudan University, Shanghai, China.; 3 Department of Otolaryngology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Journal:Ann Otol Rhinol Laryngol. 2019 Apr;128(4):286-292. doi: 10.1177/0003489418819551. Epub 2018 Dec 17.

9:Imaging of Meniere Disease.
Authors:Bernaerts A, De Foer B
Institution:Department of Radiology, GZA Hospitals Antwerp, Oosterveldlaan 24, Wilrijk 2610, Belgium. Electronic address: Belgium.
Journal:Neuroimaging Clin N Am. 2019 Feb;29(1):19-28. doi: 10.1016/j.nic.2018.09.002.

10:Clinical Characteristics of Bilateral Meniere's Disease in a Single Asian Ethnic Group.
Authors:Suh MJ, Jeong J, Kim HJ, Jung J, Kim SH
Institution:Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea. Hospital, Goyang, South Korea. South Korea. South Korea. South Korea. Korea.
Journal:Laryngoscope. 2019 May;129(5):1191-1196. doi: 10.1002/lary.27423. Epub 2018 Oct 3.

11:Intratympanic Therapies in Meniere Disease: Evaluation of Outcomes and Early Vertigo Control.
Authors:Naples JG, Henry L, Brant JA, Eliades SJ, Ruckenstein MJ
Institution:Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania, U.S.A.; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, U.S.A.
Journal:Laryngoscope. 2019 Jan;129(1):216-221. doi: 10.1002/lary.27392. Epub 2018 Oct 3.

12:Endolymphatic hydrops severity in magnetic resonance imaging evidences disparate vestibular test results.
Authors:Perez-Fernandez N, Dominguez P, Manrique-Huarte R, Calavia D, Arbizu L, Garcia-Eulate R, Alvarez-Gomez L, Guajardo C, Zubieta JL
Institution:Department of Otorhinolaryngology, Clinica Universidad de Navarra, Universidad de Navarra, Spain. Electronic address: Spain. Navarra, Spain. Navarra, Spain. Spain. Navarra, Spain. Navarra, Spain. Spain.
Journal:Auris Nasus Larynx. 2019 Apr;46(2):210-217. doi: 10.1016/j.anl.2018.08.014. Epub 2018 Sep 8.

13:Meniere's disease with unremitting floating sensation is associated with canal paresis, gravity-sensitive dysfunction, mental illness, and bilaterality.
Authors:Kitahara T, Sakagami M, Ito T, Shiozaki T, Kitano K, Yamashita A, Ota I, Wada Y, Yamanaka T
Institution:Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Kashihara, Nara, Japan. Electronic address:
Journal:Auris Nasus Larynx. 2019 Apr;46(2):186-192. doi: 10.1016/j.anl.2018.07.003. Epub 2018 Jul 30.

14:High-Frequency Horizontal Semicircular Canal Function in Certain Meniere's Disease.
Authors:Jerin C, Maxwell R, Gurkov R
Institution:German Center for Vertigo and Balance Disorders and Department of Otorhinolaryngology - Head and Neck Surgery, Grosshadern Medical Center, University of Munich, Munich, Germany.
Journal:Ear Hear. 2019 Jan/Feb;40(1):128-134. doi: 10.1097/AUD.0000000000000600.

15:Relationship Between Audio-Vestibular Functional Tests and Inner Ear MRI in Meniere's Disease.
Authors:Quatre R, Attye A, Karkas A, Job A, Dumas G, Schmerber S
Institution:Department of Otolaryngology-Head and Neck Surgery, Grenoble Alpes University Hospital, Grenoble, France. University Hospital, Grenoble, France. Hospital, Saint Etienne, France. Hospital, Grenoble, France. Hospital, Grenoble, France.
Journal:Ear Hear. 2019 Jan/Feb;40(1):168-176. doi: 10.1097/AUD.0000000000000584.

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