Meniere's Disease
February 2018 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Meniere's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Meniere's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Meniere's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Meniere's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:MRI in otology: applications in cholesteatoma and Meniere's disease.
Authors:Lingam RK, Connor SEJ, Casselman JW, Beale T
Institution:London Northwest Healthcare NHS Trust, London, UK.
Journal:Clin Radiol. 2018 Jan;73(1):35-44. doi: 10.1016/j.crad.2017.09.002. Epub 2017 Sep 29.

2:Selective Window Application of Gentamicin+ Dexamethasone in Meniere's Disease.
Authors:Ardic FN, Tumkaya F, Aykal K, Cabuk B
Institution:Department of Otolaryngology, Pamukkale University School of Medicine, Denizli, Turkey.
Journal:J Int Adv Otol. 2017 Aug;13(2):243-246. doi: 10.5152/iao.2017.3483. Epub 2017 Jul 17.

3:Effects of Selective Seratonine Re-Uptake Inhibitors on Meniere's Disease.
Authors:Kiroglu O, Surmelioglu O, Kiroglu M
Institution:Department of Pharmacology, Cukurova University School of Medicine, Adana, Turkey.
Journal:J Int Adv Otol. 2017 Aug;13(2):276-278. doi: 10.5152/iao.2017.3042. Epub 2017 Jun 21.

4:Intratympanic Dexamethasone in the Treatment of Meniere's Disease: A Comparison of Two Techniques.
Authors:Beyea JA, Instrum RS, Agrawal SK, Parnes LS
Institution:*Department of Otolaryngology-Head and Neck Surgery, Schulich School of Medicine and Dentistry, Western University, London daggerDepartment of Otolaryngology, Queen's University School of Medicine, Kingston double daggerDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Journal:Otol Neurotol. 2017 Jul;38(6):e173-e178. doi: 10.1097/MAO.0000000000001437.

5:Current Management Practices in Meniere's Disease.
Authors:Clyde JW, Oberman BS, Isildak H
Institution:*College of Medicine daggerDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania.
Journal:Otol Neurotol. 2017 Jul;38(6):e159-e167. doi: 10.1097/MAO.0000000000001421.

6:Assessment of endolymphatic hydrops and otolith function in patients with Meniere's disease.
Authors:Okumura T, Imai T, Takimoto Y, Takeda N, Kitahara T, Uno A, Kamakura T, Osaki Y, Watanabe Y, Inohara H
Institution:Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Journal:Eur Arch Otorhinolaryngol. 2017 Mar;274(3):1413-1421. doi: 10.1007/s00405-016-4418-2. Epub 2016 Dec 10.

7:A three-dimensional analysis of the endolymph drainage system in Meniere disease.
Authors:Monsanto RD, Pauna HF, Kwon G, Schachern PA, Tsuprun V, Paparella MM, Cureoglu S
Institution:Department of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis, Minnesota, U.S.A. Sorocaba Hospital, Sorocaba, Sao Paulo, Brazil. Minneapolis, Minnesota, U.S.A. University, Campinas, Sao Paulo, Brazil. Minneapolis, Minnesota, U.S.A. Minneapolis, Minnesota, U.S.A. Minneapolis, Minnesota, U.S.A. Minneapolis, Minnesota, U.S.A. Minneapolis, Minnesota, U.S.A.
Journal:Laryngoscope. 2017 May;127(5):E170-E175. doi: 10.1002/lary.26155. Epub 2016 Jul 21.

8:Efficacy and safety of betahistine treatment in patients with Meniere's disease: primary results of a long term, multicentre, double blind, randomised, placebo controlled, dose defining trial (BEMED trial).
Authors:Adrion C, Fischer CS, Wagner J, Gurkov R, Mansmann U, Strupp M
Institution:German Center for Vertigo and Balance Disorders, University Hospital Munich, Campus Grosshadern, Munich, Germany Institute for Medical Informatics, Biometry, and Epidemiology, University of Munich, Campus Grosshadern. Campus Grosshadern, Munich, Germany. Munich. Munich, Campus Grosshadern. Campus Grosshadern, Munich, Germany Department of Neurology, University Hospital Munich, 81377 Munich
Journal:BMJ. 2016 Jan 21;352:h6816. doi: 10.1136/bmj.h6816.

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